Decoding hypoxia-induced DNA Methylation patterns in Meningioma tumorigenesis

ABSTRACT: Tumor development relies on numerous factors, including the capacity to adapt to hypoxic conditions. Hypoxic microenvironment is a critical driver of the malignant phenotype, which is often correlated with meningioma grade, aggressive behavior, therapeutic resistance, and higher recurrence rates, leading to poor prognosis. Epigenetic alterations are key regulators of gene expression. Changes in DNA methylation patterns are the most extensively characterized epigenetic modifications associated with tumorigenesis. Metastasis, severity, and recurrence of meningioma have all been associated with hypo- and hypermethylation of various genes. We aim to identify the hypoxia-induced genome-wide DNA methylation profile of meningioma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE282351 | GEO | 2026/02/18

REPOSITORIES: GEO