Transcriptomics

Dataset Information

26

Miz-1 is required to coordinate the pre-TCR-dependent transitional step in DN3/DN4 thymocytes


ABSTRACT: Lineage negative, CD44 negative, CD25 positive thymocytes were isolated from wt mice or Miz1 POZ-domain knockout mice to analyze the effect of loss of Miz1 in the DN3 population of T-cells We used the mouse Affymetrix MOE430-2 microarray to characterize global gene expression changes of DN3 thymocytes from Miz1 knockout mice. Overall design: We performed microarray based gene expression profiling to determine the effect of loss of Miz1 activity on the gene expression pattern of mouse DN3 thymocytes from wt and Miz1-delta-POZ mice.

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

ORGANISM(S): Mus musculus  

SUBMITTER: Lothar Vassen  

PROVIDER: GSE28342 | GEO | 2011-08-24

SECONDARY ACCESSION(S): PRJNA139449

REPOSITORIES: GEO

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