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FSTL3 overexpressed is key factor modulating the ovarian tumor microenvironment of syngenic mouse model

ABSTRACT: This study aims to investigate the role of FSTL3 in ovarian cancer progression and treatment resistance in HGSOC, and validate FSTL3 as a potential therapeutic target. We found that FSTL3 expression was associated with a fibrotic microenvironment, correlating with an increased abundance of cancer-associated fibroblasts (CAFs), cancer cells with a more mesenchymal phenotype. Tumors overexpressing FSTL3 revealed immune evasion, notably by reducing immunocytes infiltration.

ORGANISM(S): Mus musculus

PROVIDER: GSE283618 | GEO | 2025/11/18

REPOSITORIES: GEO

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FSTL3 overexpressed is key factor modulating the ovarian tumor microenvironment of syngenic mouse model

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