Genomics

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Microarray analysis of chimeric CD4+CD28null and CD4+CD28+ T-cells in humanized mice.


ABSTRACT: The major goal of this experiment was to identify the overall changes in gene expression of human CD4+CD28 null T-cells that develop after repetitive [xeno] antigen stimulation, in comparison to normal CD4+CD28+ T-cells. These cells were derived by adoptive transfer of human CD4 T-cells from a normal donor (all CD28+) into immunodeficient mice.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28484 | GEO | 2015/01/05

SECONDARY ACCESSION(S): PRJNA139315

REPOSITORIES: GEO

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