Transcriptomics

Dataset Information

0

Targeting myeloid-PCSK9 enhancing cardio-protection beyond LDL cholesterol-lowering


ABSTRACT: Circulating Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) levels, known for regulating plasma cholesterol by degrading LDL receptors, correlate with acute myocardial infarction (AMI) risk. Recent studies suggest that PCSK9 improves cardiac function beyond LDL cholesterol levels after cardiac ischemic injury, but the precise role of PCSK9 in this process is not clarified yet. Our study reveals that PCSK9 deficiency induces heterogeneous changes in myeloid cells and macrophages, potentially protecting the heart in AMI regardless of LDL cholesterol homeostasis. Single-cell RNA sequencing identifies PCSK9-dependent cardiac macrophages (PDCMs) as reparative macrophages enriched in activator protein-1 (AP-1) transcription factor (TF)-related pathways. PDCMs enhance VEGF-C secretion and activate Akt signalling in cardiac endothelial cells, improving cardiac remodelling. Indeed, PCSK9 inhibitor-treated coronary artery disease (CAD) patients show increased myeloid cells with PDCM-like features. In sum, targeting myeloid-PCSK9 may offer cardio-protective effects through increased AP-1 activity and VEGF-C expression, providing a novel approach to prevent cardiac dysfunction in AMI.

ORGANISM(S): Mus musculus

PROVIDER: GSE285004 | GEO | 2025/07/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
GSE285004_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 3 of 3

Similar Datasets

2015-12-01 | GSE75545 | GEO
2017-03-27 | PXD005822 | Pride
2017-03-27 | PXD005835 | Pride
2021-08-05 | GSE181481 | GEO
2021-08-07 | GSE181610 | GEO
2023-09-06 | GSE227578 | GEO
| PRJNA1200779 | ENA
2022-09-22 | GSE205008 | GEO
2023-08-09 | GSE225859 | GEO
2025-01-23 | GSE232780 | GEO