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Fine particulate matter (PM2.5) induces microRNA-192–5p causing glomerular damage

ABSTRACT: To unravel changes in gene expression due to exposure to PM2.5, we performed bulk RNA-seq analyses of zebrafish larvae exposed to PM2.5 and controls. Among others, PM2.5 increased oxoglutarate alpha-ketoglutarate receptor 1a, nitric oxide synthase, arachidonate 5-lipoxygenase b, immunity-related GTPase family e1, sulfotransferase family 5A, and macrophage expressed 1. NADPH oxidase organizer 1a and NADPH oxidase 1 were upregulated due to PM2.5 exposure. Furthermore, protein tyrosine/serine/threonine phosphatase activity was decreased after exposure to PM2.5. GESA analysis showed that genes involved in proteasome complex formation, inflammatory and immune response, leucocyte-mediated cytotoxicity, peptidase activator activity protein folding, and apoptotic signaling were upregulated after exposure to PM2.5. These results indicate that PM2.5 exposure caused the activation of immune-inflammatory and oxidative stress pathways and lipid and metabolic dysregulation.

ORGANISM(S): Danio rerio

PROVIDER: GSE285038 | GEO | 2025/05/05

REPOSITORIES: GEO

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