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LMO1 expression in neuroblastoma cells reprograms tumor-associated macrophages to promote metastasis.

ABSTRACT: Our earlier study has showed that the transcriptional coactivator LMO1 synergizes with the MYCN oncogene to enhance NB tumorigenesis and metastasis. To better understand how these two oncogenes cooperate during NB development, we performed single-cell RNA sequencing analysis on primary tumors from transgenic zebrafish with overexpression of MYCN, either alone or in combination with LMO1. Interestingly, we found significantly enriched signaling pathways involved in biogenesis and metabolism in NB cells with overexpression of LMO1 and MYCN. In addition, the macrophage populations from the two tumor types were distinctly clustered.

ORGANISM(S): Danio rerio

PROVIDER: GSE285755 | GEO | 2026/02/12

REPOSITORIES: GEO

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