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Massively parallel reporter assays identify functional enhancer variants at QT interval GWAS loci


ABSTRACT: Our goal here is to utilize massively parallel reporter assays (MPRA) to screen for enhancer variants that can explain the observed common variants-based associations with QT interval at GWAS mapped loci. Towards this goal, we selected 1,018 bi-allelic variants that are associated with QT interval variation across 35 GWAS loci and overlap cardiac open chromatin regions, and performed MPRA-based screen in mouse cardiomyocyte HL-1 cells for variant-centered elements that act as enhancers and have significant allelic difference in their activities.

ORGANISM(S): Mus musculus Escherichia coli

PROVIDER: GSE286052 | GEO | 2026/07/07

REPOSITORIES: GEO

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GSE286052_RAW.tar Raw
GSE286052_mpra_qtigc_pgl4v1_pool1.txt.gz Txt
GSE286052_mpra_qtigc_pgl4v1_pool2.txt.gz Txt
GSE286052_mpra_qtigc_pgl4v2_pool1.txt.gz Txt
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