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Neutrophil dichotomy drives lymphatic metastasis

ABSTRACT: The study provides an alternative scenario in which the response of the tumor cell population itself determines the pro-tumor versus anti-tumor outcome of neutrophil-tumor interaction. Experimentally, we show that neutrophils, which were sequentially stimulated by bacteria and tumor cell secreted factors, killed a certain proportion of tumor target cells. However, the majority of the tumor cells remained resistant to this neutrophil-mediated killing and underwent a phenotype switch that was reminiscent of partial epithelial-to-mesenchymal transition. This phenotypic switch was associated with physical escape from NK killing and resulted in enhanced lymphatic metastasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE287001 | GEO | 2025/03/27

REPOSITORIES: GEO

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Neutrophil dichotomy drives lymphatic metastasis

Project description:Neutrophil dichotomy drives lymphatic metastasis

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