Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Neutrophil dichotomy drives lymphatic metastasis

ABSTRACT: Neutrophil dichotomy drives lymphatic metastasis

PROVIDER: PRJNA1210645 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32000400.fastq.gz	Fastqsanger.gz
	SRR32000401.fastq.gz	Fastqsanger.gz
	SRR32000402.fastq.gz	Fastqsanger.gz
	SRR32000403.fastq.gz	Fastqsanger.gz
	SRR32000404.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 72

Similar Datasets

Neutrophil dichotomy drives lymphatic metastasis

Project description:The study provides an alternative scenario in which the response of the tumor cell population itself determines the pro-tumor versus anti-tumor outcome of neutrophil-tumor interaction. Experimentally, we show that neutrophils, which were sequentially stimulated by bacteria and tumor cell secreted factors, killed a certain proportion of tumor target cells. However, the majority of the tumor cells remained resistant to this neutrophil-mediated killing and underwent a phenotype switch that was reminiscent of partial epithelial-to-mesenchymal transition. This phenotypic switch was associated with physical escape from NK killing and resulted in enhanced lymphatic metastasis.

2025-03-27 | GSE287001 | GEO

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Project description:Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

| PRJNA833469 | ENA

miRNA Expression in 4 mouse Hepatocellular Carcinoma cells with different lymphatic metastasis potentials

Project description:The purpose of this study is to screen for microRNAs related to lymphatic metastasis in mouse Hepatocellular Carcinoma cells, named H22, Hepa1-6, Hca-P, and Hca-F. The lymphatic metastasis abilities of the cell lines are different.

2018-03-10 | GSE111614 | GEO

circNFIB suppresses lymphatic metastasis of pancreatic cancer

Project description:circNFIB suppresses lymphatic metastasis of pancreatic cancer

| PRJNA562706 | ENA

CircNCOR1 suppresses lymphatic metastasis in bladder cancer

Project description:CircNCOR1 suppresses lymphatic metastasis in bladder cancer

| PRJNA789492 | ENA

Lymphatic dysfunction drives inflammatory temporomandibular joint osteoarthritis (TMJOA) and pain

Project description:Temporomandibular joint (TMJ) arthritis is a craniofacial disorder characterized by joint dysfunction and orofacial pain. Despite of its established roles in fluid and immune regulation, lymphatic regulation, and function in TMJ remain unknown. Using genetic report mouse, uDISCO tissue clearing, and 3D volume imaging, we defined lymphatic vessel morphology, structure, anatomic location in adult mouse TMJ. We demonstrate in a mouse model of TMJ osteoarthritis (TMJOA) that arthritis induces inflammatory lymphangiogenesis and leads to impaired synovial lymphatic functions, including decreases in synovial influx and lymph node fluid drainage. To establish the causative link between lymphatic remodeling and TMJOA, we performed lymphatic loss- and gain-of-function studies. Lymphatic deficiency exacerbated cartilage defects, bone loss, synovitis, synovial fibrosis, and pain behaviors in TMJOA mice. Conversely, lymphatic activation via a hydrogel-mediated VEGF-C delivery to TMJ reduced TMJ pain, inflammation, and arthritis-like pathogenesis. Therefore, we defined lymphatic structure in TMJ and found that lymphatic dysfunction drives TMJOA pathogenesis and pain, suggesting its potential as a therapeutic target.

2025-06-25 | GSE295404 | GEO

Foxo1 Drives the TGFβ1-Dependent Dichotomy of Th17 Cell Fates

Project description:Foxo1 Drives the TGFβ1-Dependent Dichotomy of Th17 Cell Fates

| PRJNA1023848 | ENA

CircTLCD4-RWDD3 promotes lymphatic metastasis in non-small cell lung cancer

Project description:Lung cancer is the leading cause of cancer-related death worldwide, and non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers. Lymphatic metastasis serves as a predominant NSCLC metastatic route and an essential predictor of patient prognosis. Recently, circular RNA (circRNA) has emerged as critical mediator in various tumor initiation and progression. To identify essential circRNA that involves in the lymphatic metastasis of NSCLC, Next generation sequencing (NSG) was performed in 6 paired NSCLC tissues and normal adjacent tissues (NAT).

2023-12-01 | GSE235634 | GEO

exosomal ELNAT1 promotes lymphatic metastasis of bladder cancer

Project description:exosomal ELNAT1 promotes lymphatic metastasis of bladder cancer

| PRJNA657414 | ENA

NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression

Project description:Pancreatic cancer liver metastasis (PCLM) is an important factor leading to dismal prognosis. The adaptive remodeling of the tumor microenvironment (TME), especially the role of neutrophil in liver metastasis remains elusive. Here we combined single-cell sequencing combined with spatial transcriptomics on patients’ samples to characterize the landscape of PCLM, and explored the functional diversity possessed by neutrophils infiltrated in liver metastases. We identified the pivotal Neutrophils_S100A12 cluster capable of promoting metastatic progression by releasing neutrophil extracellular traps (NETs); spatially, Neutrophils_S100A12 cells are specifically distributed at the invasive front of the metastatic lesions. Mechanistically metastatic TME activates canonical TGF-β/SMAD3 signaling within neutrophil, resulting in NFE2-mediated phenotypic polarization; furthermore NFE2 induces NETs generation by up-regulating PADI4 expression. Interference with NFE2 activation in neutrophils prevents phenotypic conversion and reduces liver metastasis. Our data demonstrate that NFE2-mediated neutrophil polarization in PCLM is a potential target for anti-metastatic therapy.

2025-01-18 | GSE281288 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data