Transcriptomics

Dataset Information

22

Inflammation and Extracellular Matrix Genes Differentially Expressed Following Overlapping Zotarolimus- and Sirolimus-Eluting Stent Implantation


ABSTRACT: An unanticipated complication of the use of bare metal stents in percutaneous transluminal coronary angioplasty is in-stent restenosis resulting in >50% late lumen diameter loss in treated patients. In an effort to reduce in-stent restenosis, drug eluting stents containing the immunosuppressant sirolimus or zotarolimus have recently been developed. We report here the molecular response of arterial tissue to the implanting of these drug-eluting stents. Overall design: Gene expression profiling was performed on 4 artery segments surrounding bare metal stents (BMS), 4 artery segments surrounding sirolimus-eluting stents (SES), and 4 artery segments surrounding zotarolimus-eluting stents (ZES) implanted into porcine animal models for 28 days.

INSTRUMENT(S): [Porcine] Affymetrix Porcine Genome Array

ORGANISM(S): Sus scrofa  

SUBMITTER: Andrew D Huang   

PROVIDER: GSE28781 | GEO | 2011-04-22

SECONDARY ACCESSION(S): PRJNA138681

REPOSITORIES: GEO

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