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GPNMB is a marker of invasive quiescent differentiated melanoma cells driven by tumor niche reprogramming

ABSTRACT: We provide evidence of the existence of a slow cycling melanoma population isolated in vivo from melanoma PDXs using the H2B-GFP system. Single cell transcriptomic analysis unveils a significant transcriptional heterogeneity of GFP-retaining slow cycling cells, defining a quiescent subpopulation of cells. These cells show a different phenotype in primary tumors and matched metastases, suggesting that tumor niche pressure drives a transcriptional reprogramming of quiescent cells during melanoma progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE288622 | GEO | 2025/05/29

REPOSITORIES: GEO

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GPNMB is a marker of invasive quiescent differentiated melanoma cells driven by tumor niche reprogramming

Project description:We provide evidence of the existence of a slow cycling melanoma population isolated in vivo from melanoma PDXs using the H2B-GFP system. Single cell transcriptomic analysis unveils a significant transcriptional heterogeneity of GFP-retaining slow cycling cells, defining a quiescent subpopulation of cells. These cells show a different phenotype in primary tumors and matched metastases, suggesting that tumor niche pressure drives a transcriptional reprogramming of quiescent cells during melanoma progression.

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