Prostaglandin and prostacyclin regulation of Th1 responses [ptgir_ko]

ABSTRACT: Metabolic reprogramming is an integral component of normal Th1 induction and contraction. Whereas Th1 inducing signals are largely defined, the pathways underlying timely Th1 contraction remain poorly understood. Here, we show that a CD4+ T cell-intrinsic prostanoid lipid mediator production and signaling machinery, controlled by cell-autonomous complement C5, governs the Th1 shutdown program.

ORGANISM(S): Mus musculus

PROVIDER: GSE288921 | GEO | 2025/06/12

REPOSITORIES: GEO