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Protective effect of mesaconate on autoimmune hepatitis via suppression of inflammatory response and oxidative stress

ABSTRACT: Autoimmune hepatitis (AIH) is a severe immune-mediated inflammatory liver disease that currently lacks feasible drug treatment. Existing evidence suggests that mesaconate (MSA) exhibits immunomodulatory capacities, however, its role in AIH remains unclear. Here, we constructed a mouse model of AIH by administering concanavalin A (ConA) and conducted prophylactic administration to investigate the pharmacological effect of MSA on AIH and the underlying mechanisms of action. We found that pretreatment with MSA can effectively mitigate ConA-induced AIH by dampening the inflammatory response, oxidative stress, and apoptosis, both in vivo and in vitro. The underlying protective mechanism is associated with the inhibition of the IFN-γ-JAK1/2-STAT1 signaling pathway by MSA. Overall, our research not only validates the therapeutic potential of MSA for the management of AIH for the first time, but also provides a novel perspective and a promising therapeutic candidate for the future treatment of autoimmune disorders.

ORGANISM(S): Mus musculus

PROVIDER: GSE289607 | GEO | 2025/12/02

REPOSITORIES: GEO

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