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BMAL2 controls adipose tissue inflammation and metabolic adaptation during obesity

ABSTRACT: We profile the transcripts of adipose progenitors defined as CD45-CD31-PDGFRb+ isolated from eWAT of wild-type and Bmal2-/- C57BL/6J mice fed with normal diet or high-fat diet for 12 weeks. We show that Bmal2 invalidation strongly impacts the transcriptome profile in adipose progenitors and, when associated with obesogenic diet, enhances its deleterious effects. Loss of Bmal2 alters metabolic and maintenance pathways in adipose progenitors and strongly enhances their inflammatory function during diet-induced obesity.

ORGANISM(S): Mus musculus

PROVIDER: GSE289800 | GEO | 2025/09/21

REPOSITORIES: GEO

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