Unknown

Dataset Information

0

Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth


ABSTRACT: Alteration of the PTEN/PI3K pathway is associated with late stage and castrate resistant prostate cancer (CRPC). However, how PTEN loss involves in CRPC development is not clear. Here we show that castration-resistant growth is an intrinsic property of Pten-null prostate cancer (CaP) cells, independent of cancer development stage.PTEN loss suppresses androgen-responsive gene expressions by modulating androgen receptor (AR) transcription factor activity. Conditional deletion of AR in the epithelium promotes the proliferation of Pten-null cancer cells, at least in part, by down-regulating androgen-responsive gene FKBP5 and preventing PHLPP-mediated AKT inhibition. Our findings identify PI3K and AR pathway crosstalk as a mechanism of CRPC development, with potentially important implications for CaP etiology and therapy

ORGANISM(S): Mus musculus

PROVIDER: GSE29010 | GEO | 2011/05/03

SECONDARY ACCESSION(S): PRJNA140463

REPOSITORIES: GEO

Similar Datasets

2011-05-03 | E-GEOD-29010 | biostudies-arrayexpress
2023-10-11 | MTBLS8034 | MetaboLights
2023-08-23 | GSE233306 | GEO
2023-09-19 | GSE228283 | GEO
2022-12-15 | GSE208321 | GEO
2016-06-30 | E-GEOD-61630 | biostudies-arrayexpress
2014-09-10 | E-GEOD-58478 | biostudies-arrayexpress
2012-05-22 | E-GEOD-35988 | biostudies-arrayexpress
2015-04-03 | E-GEOD-67537 | biostudies-arrayexpress
2012-10-02 | E-GEOD-40050 | biostudies-arrayexpress