GNL3 orchestrates AR transcriptional programs to drive castration-resistant prostate cancer and immune evasion

ABSTRACT: Androgen receptor (AR) signaling is a primary oncogenic driver of castration-resistant prostate cancer (CRPC), yet the mechanism remains incompletely understood. Dysregulation of the AR co-regulatory network has emerged as a key driver of castration resistance. To identify AR-interacting proteins linked to CRPC progression, we performed proteomics-based rapid immunoprecipitation of endogenous proteins (RIME) analysis targeting AR in the CRPC cell line C4-2B.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Malignant Cell, Cell Culture

DISEASE(S): Prostate Cancer

SUBMITTER: Cuiting Zhang  

LAB HEAD: Edwin Cheung

PROVIDER: PXD067138 | Pride | 2026-06-08

REPOSITORIES: Pride