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Effect of Ref-1 redox inhibition with APX2009 on gene expression in human retinal endothelial cells

ABSTRACT: Ischemic retinopathies, such as proliferative diabetic retinopathy (PDR) and retinopathy of prematurity (ROP), are characterized by abnormal retinal neovascularization. Current therapeutic interventions for these diseases include intravitreal injections of anti-VEGF biologics, which face multiple limitations due to variable patient response and utilization of alternative pathways to promote angiogenesis. APE1/Ref-1, a protein with both DNA endonuclease and redox regulatory functions, may be a novel therpautic target for proliferative retinopathies, because the redox function of Ref-1 modulates multiple signaling pathways involved in angiogenesis and inflammation. Here, we aimed to identify novel signaling pathways regulated by Ref-1 redox activity using RNA sequencing of human retinal endothelial cells treated with Ref-1 redox inhibitor APX2009.

ORGANISM(S): Homo sapiens

PROVIDER: GSE290559 | GEO | 2025/09/24

REPOSITORIES: GEO

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