Accumulation of mutant Z α1-Antitrypsin impairs intestinal function in mice

ABSTRACT: We found that accumulation of mutant Z α1-Antitrypsin in intestinal cells, and in particular in Paneth cells, induces activation of proteotoxic pathways leading to impaired intestinla homeostasis in PiZ mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE291017 | GEO | 2026/06/29

REPOSITORIES: GEO