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Transcriptomic Analysis of WT and IGF2BP2 KO Macrophages Reveals Metabolic Alterations

ABSTRACT: This dataset contains RNA-Seq data from wild-type (WT) and IGF2BP2 knockout (KO) bone marrow-derived macrophages (BMMs) under basal and IL-4-stimulated conditions. Loss of IGF2BP2 led to significant transcriptional changes, particularly in genes regulating metabolism, mitochondrial function, and cell migration. Pathway analysis revealed a metabolic shift toward glycolysis and reduced migratory capacity. Details: Int J Biol Sci 2026; 22(6):2754-2773. doi:10.7150/ijbs.122142

ORGANISM(S): Mus musculus

PROVIDER: GSE292558 | GEO | 2026/03/01

REPOSITORIES: GEO

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