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Differential gene expression of adult rat retinas exposed to light.

ABSTRACT: We performed a microarray screening of adult rat retinas to identify genes that could show and up- or down-regulation due to exposure to light.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE29299 | GEO | 2011/10/30

SECONDARY ACCESSION(S): PRJNA138627

REPOSITORIES: GEO

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Differential gene expression of adult rat retinas exposed to light.

Project description:We performed a microarray screening of adult rat retinas to identify genes that could show and up- or down-regulation due to exposure to light. This study was performed using ex-vivo retinas collected from adult Long Evans rats that were exposed to light (1000 Lux), or were left in dark as control. All experiments were performed at the same hour, so that the contribution from the circadian rhythm would not affect the observations. The hours to which the experiment was performed were at 7am (always in dark), 10am (under 1000 lux) and as control 10am (always kept in dark), 1pm (under 1000 Lux) and 1pm (Always in dark).

2011-10-29 | E-GEOD-29299 | biostudies-arrayexpress

Transcription profiling of mouse BALBc albino retinas compared BETWEEN dark adapted AND light damaged animals

Project description:Transcriptional profiles were compared between dark adapted and light damaged BALBc (albino) mouse retinas. Experiment Overall Design: BALBc mice were dark adapted for one week. To produce light damage a subset of the mice were then exposed to 6,000 lux white fluorescent light for 6 hours. Retinas were collected for RNA extraction 24 hours after light damage.

2008-04-07 | E-GEOD-10528 | biostudies-arrayexpress

The retinal transcriptional response to light damage

Project description:Transcriptional profiles were compared between dark adapted and light damaged BALBc (albino) mouse retinas. Keywords: stress response

2008-02-15 | GSE10528 | GEO

Proteomic Analysis of Diabetic Retinas

Project description:As a metabolic disease, diabetes often leads to health complications such as heart failure, nephropathy, neurological disorders, and vision loss. Diabetic retinopathy (DR) affects as many as 100 million people worldwide. The mechanism of DR is complex and known to impact both neural and vascular components in the retina. While recent advances in the field have identified major cellular signaling contributing to DR pathogenesis, little has been reported on the protein post-translational modifications (PTM) -known to define protein localization, function, and activity -in the diabetic retina overall. Protein glycosylation is the enzymatic addition of carbohydrates to proteins, which can influence many protein attributes including folding, stability, function, and subcellular localization. Olinked glycosylation is the addition of sugars to an oxygen atom in amino acids with a free oxygen atom in their side chain (i.e., threonine, serine). To date, more than 100 congenital disorders of glycosylation have been described. However, no studies have identified the retinal O-linked glycoproteome in health or disease. With a critical need to expedite the discovery of PTMomics in diabetic retinas, we identified both global changes in protein levels and the retinal O-glycoproteome of control and diabetic mice. Liquid chromatography/mass spectrometry-based glycoproteomics and high throughput screening identified proteins differentially glycosylated in the retinas of wildtype and diabetic mice. Here, we provide evidence that diabetes shifts O-glycosylation of metabolic and synaptic proteins in the retina.

2023-08-16 | PXD044269 | Pride

A polymer optoelectronic interface restores light sensitivity in blind rat retinas.

Project description: Not available

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Transplanted neurons integrate into adult retinas and respond to light.

Project description: Not available

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Mouse iPS cells-derived 3D-retinas: Vehicle control- vs. 4-hydroxytamoxifen (4-OHT)-treated 3D-retinas

Project description:Transcriptional profiling of 3D-retinas differentiated from mouse iPS cells comparing vehicle control- with 4-OHT-treated. 4-OHT is an inverse agonist of estrogen-related receptor beta (ERRÎ²), a rod-enriched transcription factor responsible for maintenance of rod photoreceptor cells and the treatment induces photoreceptor specific cell death in the 3D-retinas. Goal was to understand the mechanism of 4-OHT-induced degeneration of photoreceptor cells in the 3D-retinas. 4-OHT-induced gene expression in the 3D-retinas was measured at DD 26 when the photoreceptor cells were degenerated. Two-condition experiment, vehicle control- vs. 5 ÂµM 4-OHT-treated 3D-retinas. Biological replicates: each sample has 24 3D-retinas and 1 replicate.

2016-07-05 | E-GEOD-83985 | biostudies-arrayexpress

Proteomic Analysis of Diabetic Retinas (proteoglycomics data only)

2023-08-16 | PXD044270 | Pride

Mouse iPS cells-derived 3D-retinas: Vehicle control- vs. 4-hydroxytamoxifen (4-OHT)-treated 3D-retinas

2016-07-05 | GSE83985 | GEO

Mouse iPS cells-derived 3D-retinas: Vehicle control- vs. 4-hydroxytamoxifen (4-OHT)-treated 3D-retinas w/o supplements

Project description:Transcriptional profiling of 3D-retinas differentiated from mouse iPS cells comparing vehicle control with 4-OHT-treated w/o supplements. 4-OHT is an inverse agonist of estrogen-related receptor beta (ERRÎ²), a rod-enriched transcription factor responsible for maintenance of rod photoreceptor cells and the treatment induces photoreceptor specific cell death in the 3D-retinas. Goal was to understand the mechanism of protective effects of representative ophthalmic supplements for treating the photoreceptor degeneration. 4-OHT w/o supplements-induced gene expression in the 3D-retinas was measured at DD 25 when the photoreceptor cells started to be degenerated. Four-condition experiment, vehicle control- vs. 5 ÂµM 4-OHT- vs. 5 ÂµM 4-OHT with 400 ÂµM vitamin E- vs. 5 ÂµM 4-OHT with 200 nM lutein-treated 3D-retinas. Biological replicates: each sample has 24 3D-retinas and 1replicate.

2016-07-05 | E-GEOD-83984 | biostudies-arrayexpress

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