Whole genome CRISPR drop-out screen in THP-1 cells exposed to mebendazole

ABSTRACT: We previously reported that mebendazole is an effective anti-AML therapeutic and acts via induction of MYB degradation. The present experiemnt was performed in order to uncover pathways of potential resistance in AML cells to mebendazole exposure. A whole genome CRISPR drop-out screen was performed on THP-1 AML cells exposed to 1 micromolar mebendazole or DMSO in order to identify genes that decreased AML sensitivity to this drug.

ORGANISM(S): Homo sapiens

PROVIDER: GSE293063 | GEO | 2026/04/01

REPOSITORIES: GEO