Histon lactylation drives HAS2 expression in gastric cancer tumorigensis after H.pylori infection

ABSTRACT: Histone lactylation, an epigenetic modification, promotes tumor growth and immune evasion in various cancers. Our study found increased pan-lysine lactylation and H3K18la in gastric tissues, linked to poor prognosis. Inhibiting glycolysis and silencing lactate dehydrogenase reduced H3K18la, boosting CD8+ T-cell activity against gastric cancer. H3K18la activated HAS2 transcription, enhancing MYC nuclear transport and PD-L1 expression..Our data provide a molecular framework for Histone lactylation in the process of gastric cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE293976 | GEO | 2026/04/09

REPOSITORIES: GEO