Transcriptomics

Dataset Information

0

Acquisition of neural crest promoted thyroid evolution from chordate endostyle


ABSTRACT: The endostyle is an endodermal organ unique to non-vertebrate chordates except for lamprey larvae, where it serves as forerunner to the adult thyroid. Here, we examine if the acquisition of neural crest in the vertebrate lineage played a role in the elaboration of the endostyle. CM-DiI lineage tracing reveals a neural crest contribution to the endostyle, and CRISPR/Cas9 mutagenesis of key neural crest genes causes endostyle defects including formation of a single rather than bilobed structure. RNA-sequencing reveals gene profiles characteristic of embryonic neural crest cells and Schwann cell precursors in the developing endostyle. Contrasting with the prevailing view that the endostyle is an endoderm-derived organ, we propose that the acquisition of the neural crest played a critical step in promoting thyroid evolution from chordate endostyle.

ORGANISM(S): Petromyzon marinus

PROVIDER: GSE294220 | GEO | 2025/08/07

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA1248746 | ENA
2024-02-22 | GSE246248 | GEO
| PRJNA497902 | ENA
2024-03-29 | GSE198493 | GEO
2024-03-29 | GSE198492 | GEO
2024-03-29 | GSE198491 | GEO
2014-09-01 | GSE50487 | GEO
2019-05-14 | GSE131136 | GEO
2023-09-01 | GSE240190 | GEO
2021-11-11 | GSE178969 | GEO