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Skin commensal Staphylococcus promotes systemic reconfiguration of Vγ6+ γδT cells

ABSTRACT: Skin-resident Staphylococcus aureus, a common human commensal, can shape systemic immune responses without provoking inflammation in mice. This study demonstrates that topical skin colonization with live S. aureus robustly expands IL-17-producing Vγ6⁺ γδT17 cells both locally in the dermis and across distant tissues, including mucosal, lymphoid, and metabolic organs. This systemic reconfiguration is IL-1R-dependent yet independent of IL-23, TLR2, or the microbiota. Transcriptomic profiling reveals a transitional state in dermal Vγ6⁺ γδT cells, marked by changes in tissue-residency and migration-associated genes. Local proliferation, lymphatic trafficking and long-term recirculation sustain this response, even without systemic bacterial dissemination. These findings uncover a previously unrecognized allostatic process by which localized microbial signals recalibrate systemic immunological setpoints. The study expands our understanding of γδT17 cell dynamics and highlights their potential in tuning organismal fitness.

ORGANISM(S): Mus musculus

PROVIDER: GSE294609 | GEO | 2026/04/01

REPOSITORIES: GEO

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