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Engineered cytokine-secreting cells to prevent foreign body response against implants

ABSTRACT: Foreign body response hinders the long-term functionality of implants such as microencapsulated cell therapies. To address this issue, we delivered encapsulated engineered cells that secrete targeted cytokines to mitigate fibrosis on microcapsules. Here, we quantify immune profile change due to these encapsulated cytokine-secreting cells in mice. We identified that IL10 prevents inflammatory response while IL12 impairs the TGF-beta pathway to mitigate fibrosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE294864 | GEO | 2026/04/06

REPOSITORIES: GEO

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