Miconazole attenuates LPS-induced lung inflammation by modulating alveolar macrophage polarization through the regulation of lipid metabolism
Ontology highlight
ABSTRACT: Miconazole (MCZ), an antifungal agent with anti-inflammatory potential, was evaluated in a lipopolysaccharide (LPS)-induced mouse model of lung inflammation.MCZ reduced inflammatory cell infiltration, suppressed the expression of inflammatory factors, and alleviated lung injury.Single-cell RNA sequencing revealed that MCZ decreased pro-inflammatory alveolar macrophages (AM1) and increased anti-inflammatory AM2 subsets, accompanied by a shift from lipid synthesis to lipid catabolism.MCZ also disrupted the interactions between inflammatory cells in vitro and regulated the polarization of macrophages by promoting the expression of CD206 and reducing the expression of CD86 and PLIN3.These findings highlight MCZ as a potential therapeutic agent for pulmonary inflammation via lipid metabolic reprogramming and immune modulation.
ORGANISM(S): Mus musculus
PROVIDER: GSE295628 | GEO | 2026/01/05
REPOSITORIES: GEO
ACCESS DATA