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Piezo1 mediates the growth of myoblasts in a microgravity environment

ABSTRACT: Skeleton muscle atrophy during prolonged spaceflight poses a significant health challenge for manned space missions, with its underlying molecular mechanisms remaining incompletely understood, particularly regarding how microgravity affects skeletal muscle through mechanotransduction pathways. This study investigates the pivotal role of mechanosensitive Piezo1 channels in myoblast regeneration. Utilizing a two-dimensional clinostat to simulate microgravity and integrating multi-dimensional approaches including 3D genomics and cellular dynamics analysis, we systematically revealed that microgravity promotes C2C12 myoblast proliferation via Piezo1 activation while inducing 3D chromatin structural remodeling. This work pioneers in elucidating a novel mechanism where aberrant mechanotransduction leads to chromatin conformation dysregulation and subsequent skeleton muscle atrophy, providing theoretical foundations and innovative directions for developing mechanobiology-based countermeasures.

ORGANISM(S): Mus musculus

PROVIDER: GSE295790 | GEO | 2026/04/28

REPOSITORIES: GEO

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