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Autophagy related 14 regulates liver homeostasis and function

ABSTRACT: Autophagy regulated 14 (ATG14) is a key regulator of autophagy; however, its role in the liver remains poorly understood. This study aimed to investigate the hepatocyte-specific function of ATG14 in vivo. We generated Atg14 hepatocyte-specific knockout (HepKO) mice using adeno-associated virus (AAV) to deliver thyroxine-binding globulin (TBG) gene promoter-driven Cre into Atg14 floxed mice at an adult age and fed control and knockout mice with a Western diet for 4 weeks.

ORGANISM(S): Mus musculus

PROVIDER: GSE296179 | GEO | 2025/05/07

REPOSITORIES: GEO

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