Transcriptomics,Genomics

Dataset Information

165

Liver fibrosis model of hepatocyte-specific FOXA2 knockout mice


ABSTRACT: Liver firbrosis model of hepatocyte-specific FOXA2 knockout mice. Adeno-associated virus AAV8-TBG-Control or AAV8-TBG-Cre was injected via the tail vein of FOXA2flox/flox (FOXA2f/f) mice 2 weeks prior to CCl4 administration. Hepatic fibrosis was induced by injection of CCl4 twice per week for 4 weeks. Overall design: Adeno-associated virus AAV8-TBG-Control or AAV8-TBG-Cre was injected via the tail vein of FOXA2flox/flox (FOXA2f/f) mice 2 weeks prior to CCl4 administration. Hepatic fibrosis was induced by injection of CCl4 twice per week for 4 weeks. The mice were sacrificed on the third day after the last injection of CCl4 (0.25ml/kg BW). Total RNA was extracted from primary hepatocytes.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: xin zhang  

PROVIDER: GSE97344 | GEO | 2017-04-04

SECONDARY ACCESSION(S): PRJNA381475

REPOSITORIES: GEO

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