Target macrophage SPP1 promotes CD8 T cell infiltrations

ABSTRACT: SPP1 in tumor associated macrophages (TAM) can inhibit the infiltration of CD8 T cells, promote tumor growth, and reduce the efficacy of ICI immunotherapy. RNA sequencing data showed diffrential expressed genes and enrichment pathway in the bone marrow derived macrophages from SPP1fl/fl-Lyz2-icre mice compared to control SPP1fl/fl mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE297153 | GEO | 2026/06/30

REPOSITORIES: GEO