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Ischemic stroke/reperfusion mRNA-seq of brain and lung tissues at different time points

ABSTRACT: Ischemic stroke can trigger secondary pulmonary complications, which severely affect clinical outcomes, but the underlying dynamic pathophysiological mechanisms remain incompletely understood. Through RNA sequencing combined with temporal transcriptomic analysis of brain/lung tissues from rat models of middle cerebral artery occlusion (MCAO, 0-2 hours) and reperfusion (12h, 1d, 3d, 5d) to explore signaling mechanisms, we discovered biphasic pulmonary pathology. This process initiates with acute interleukin-1β (IL-1β)-mediated inflammation, progressing to sustained metabolic-inflammatory cascades governed by hypoxia-inducible factor 3α (HIF-3α) and ATP-binding cassette sub-family A member 6 (ABCA6). Integration revealed Forkhead Box O1 (FOXO1) as the hierarchical regulator orchestrating these pathological transitions.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE297583 | GEO | 2026/05/18

REPOSITORIES: GEO

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