Transcriptomics

Dataset Information

0

NK cells in the female reproductive tract (FRT) acquire an effector transcriptional program during menstruation


ABSTRACT: To evaluate the impact of the menstrual cycle on the transcriptional programs of NK cells in the female reproductive tract (FRT), we compared NK cells (Live lymphocytes, CD45.2+, DX5+, NK1.1+, Ly6G-, CD3-, CD19-) from the spleen and FRT of female C57BL/6J mice either treated with medroxy-progesterone acetate (MPA) or on day 8 of the pseudopregnancy / menstruation protocol. Prior to euthanasia, mice were injected intravenously with anti-CD45 antibody to discern between tissue and circulating NK cells in the FRT, with only tissue-resident cells sorted for analysis. Sorted splenic NK cells were not separated based on CD45 staining. The results indicate that FRT NK cells isolated on day 8 of the pseudopregnancy / menstruation protocol express genes associated with NK cell effector responses compared to FRT NK cells in mice treated with MPA and compared to splenic NK cells in both models.

ORGANISM(S): Mus musculus

PROVIDER: GSE297609 | GEO | 2025/05/30

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA1265255 | ENA
2013-01-09 | E-GEOD-43339 | biostudies-arrayexpress
2013-01-09 | GSE43339 | GEO
2014-04-26 | E-GEOD-52045 | biostudies-arrayexpress
2017-06-10 | GSE99809 | GEO
| PRJNA389772 | ENA
2022-02-01 | GSE129991 | GEO
2012-12-31 | E-MEXP-3507 | biostudies-arrayexpress
2016-11-24 | GSE71259 | GEO
2015-04-28 | E-GEOD-68294 | biostudies-arrayexpress