Transcriptome profiling of CT26 cells and de-differentiated CT26 cells induced by forced expresssion of Oct4 and SOX2 using RNA-sequencing.

ABSTRACT: The core proeprty of cancer cells is neural stemness, which determines tumorigenicity and pluripotency. It has been reported that neural stem cells are uniquely immune-privileged, suggesting that neural stemness also confers cancer cells with the ability of immune evasion or immune privilege. CT26 is a mouse colon cancer cell line. We found that dedifferentiation of CT26 cells with overexpression of Oct4 and SOX2 enhanced neural stemness and decreased immunogenicity in cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE298039 | GEO | 2026/05/31

REPOSITORIES: GEO