Transcriptome profiling of parental and lenvatinib-resistant TPC-1 thyroid cancer cells

ABSTRACT: To uncover transcriptional alterations associated with lenvatinib resistance in papillary thyroid carcinoma, we performed paired-end RNA-Seq (2 × 150 bp, NovaSeq 6000) on parental TPC-1 cells and an in-house generated lenvatinib-resistant sub-line (TPC-1-Len). Total RNA from three biological replicates per group was extracted with TRIzol, libraries were prepared with poly(A) selection, and sequencing was carried out at OE Biotech (Shanghai, China). Differential gene expression was analysed using DESeq2 (Q < 0.05)

ORGANISM(S): Homo sapiens

PROVIDER: GSE300132 | GEO | 2026/06/18

REPOSITORIES: GEO