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Small RNA production in E13.5 placenta of intra-cytoplasmic sperm injection(ICSI)-F2 offspring

ABSTRACT: Various behavioural abnormalities were observed in the F2 offspring of ICSI (Kanatsu-Shinohara et al., 2023, J. Clin. Invest. 133(22):e170140). The data presented here aim to clarify the cause of these abnormalities, and gene expression in the neonatal brain was investigated using RNA sequencing (RNAseq). ICSI was performed using C57BL/6 epididymal sperm and oocytes. Males from the F1 generation were naturally mated with C57BL/6 females to produce the F2 generation. Small RNA production in E13.5 placenta of ICSI-F2 offspring was examined. Each group contains 5 biological replicates.

ORGANISM(S): Mus musculus

PROVIDER: GSE300718 | GEO | 2026/04/21

REPOSITORIES: GEO

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Expression data of E13.5 placenta from intra-cytoplasmic sperm injection(ICSI)-F2 offspring

Project description:Various behavioural abnormalities and congenital anomalies were observed in the F2 offspring of ICSI (Kanatsu-Shinohara et al., 2023, J. Clin.). Invest. 133(22): e170140). The data presented here aim to clarify the cause of these abnormalities. Gene expression in the ICSI-F2 placenta was investigated using RNA sequencing (RNA-seq). ICSI was performed using C57BL/6 epididymal sperm and oocytes. Male ICSI-F2 offspring was mated with wild-type C57BL/6 female, and placentae recovered from pregnant females at E13.5 were examined for gene expression. Each group contains five biological replicates.

2026-04-21 | GSE300655 | GEO

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Expression data of E19.5 placenta from intra-cytoplasmic sperm injection(ICSI)-F1/F2 offspring

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Expression data from adult liver of offspring derived from cultured spermatogonia (GS cells) cryopreserved for a 6 months on the International Space Station (ISS) or on Earth.

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Expression data of E13.5 placenta from intra-cytoplasmic sperm injection(ICSI)-F2 offspring

Project description:Expression data of E13.5 placenta from intra-cytoplasmic sperm injection(ICSI)-F2 offspring

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Small RNA production in E13.5 placenta of intra-cytoplasmic sperm injection(ICSI)-F2 offspring

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Expression data of neonatal brain from male intra-cytoplasmic sperm injection(ICSI)-F2 offspring

Project description:Expression data of neonatal brain from male intra-cytoplasmic sperm injection(ICSI)-F2 offspring

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Effect of ICSI on DNA methylation in germline stem cells.

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