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FABP4 binding cancer cells exhibit an invasive phenotype via PKC-mitoROS signaling

ABSTRACT: Using several high-fat diet-induced murine obesity models, we demonstrate that obesity promotes breast cancer lung metastasis through elevated levels of adipocyte-derived circulating FABP4. Circulating FABP4 directly binds to a subset of breast cancer cells via the membrane lipid PIP2. This FABP4/PIP2 interaction activates PKC signaling and enhances mitochondrial ROS production, driving cancer cell migration. these findings identify circulating FABP4 as a critical mediator of obesity-driven metastasis and highlight it as a promising therapeutic target for treating metastatic breast cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE302775 | GEO | 2026/06/17

REPOSITORIES: GEO

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Spatial transcriptomics reveals distinct tumor microenvironment of murine breast cancer model undergoing treatment with a humanized monoclonal antibody targeting FABP4

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