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Differential infection tolerance mediates sex-biased illness severity in sepsis

ABSTRACT: Sepsis impacts males and females differently. Males have higher incidence, illness severity and mortality in sepsis than females. In this study, we use mouse models of fecal-induced peritonitis (FIP) to study sex disparities in sepsis. Male mice show higher illness severity, physiological derangement and end-organ dysfunction compared to females. Sex-biased outcome was driven by gonadal sex but not chromosome-linked gene effects. The results of this study indicate that male-biased sepsis severity is driven by impaired infection tolerance in males due to sex-biased mechanisms of mitochondrial function. We did not find differences in infection resistance or canonical immune/inflammatory pathways between males and female mice. Here we performed RNA-sequencing on mouse liver hepatocytes of uninfected and septic males and females.

ORGANISM(S): Mus musculus

PROVIDER: GSE303231 | GEO | 2025/07/28

REPOSITORIES: GEO

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Differential infection tolerance mediates sex-biased illness severity in sepsis

Project description:Differential infection tolerance mediates sex-biased illness severity in sepsis

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