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MERFISH profiling of mouse retinal ganglion cell layer on wholemount

ABSTRACT: We optimized a workflow combining imaging-based spatial transcriptomics (MERFISH) and immunostaining on ganglion cell layer retinal flatmounts of C57/Bl6J mice.The MERFISH data shows molecularly-defined retinal ganglion cell types types exhibited non-uniform distributions. We also analyzed local neighborhoods for each cell and registered several RGC types as enriched in the perivascular niche.

ORGANISM(S): synthetic construct Mus musculus

PROVIDER: GSE303399 | GEO | 2025/07/23

REPOSITORIES: GEO

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