Methylation profiling

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Type I and Type II fibre-type-specific and whole muscle DNA methylation profiles across both males and females before and after 12 weeks High Intensity Interval Training


ABSTRACT: Skeletal muscle is an important organ for health and movement, largely driven by specific muscle fibres. However, the assessment of fibre-type-specific DNA methylation in human skeletal muscle has been limited. We generated methylome profiles of Type I muscle fibres (T1), Type II muscle fibres (T2) and whole skeletal muscle (WM) from males and females before and after 12 weeks high intensity interval training. We compared the TI and TII pooled fibre samples (per individual) and whole muscle samples at the baseline timepoint and generated TI, TII and WM profiles of human skeletal muscle from both males and females.

ORGANISM(S): Homo sapiens

PROVIDER: GSE304045 | GEO | 2025/10/23

REPOSITORIES: GEO

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