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DNA methylation signature from acute lymphoblastic leukemia pediatric Mexican patients

ABSTRACT: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer worldwide, with higher incidence and lower survival rates observed in the Mexican population. This study aimed to characterize the genome-wide DNA methylation landscape in a cohort of Mexican pediatric ALL patients. Bone marrow (BM) or peripheral blood (PB) samples were collected at diagnosis from 53 children under 17 years old with B-cell ALL, alongside BM samples from 5 pediatric non-ALL controls. DNA methylation profiling was performed using the Illumina Infinium MethylationEPIC v2.0 array. Data processing and identification of differentially methylated positions (DMPs) were conducted using the ChAMP package in R. This dataset provides a comprehensive epigenomic resource for investigating methylation-based biomarkers and dysregulated pathways in this understudied population.

ORGANISM(S): Homo sapiens

PROVIDER: GSE306095 | GEO | 2025/12/04

REPOSITORIES: GEO

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