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Dataset Information

55

Dual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer [ChIP_seq, DHS_seq]


ABSTRACT: We report the dual role of FoxA1 in androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell line LNCaP-1F5 using ChIP-sequencing. Depletion of FoxA1 reprograms both androgen and glucocorticoid receptor recruitment and subsequent gene expression. The ChIP-seq has been performed using AR, FoxA1, GR, H3K4me2 antibodies. We have also mapped the DNaseI-hypersensitive sites (DHS) using deep sequencing. Overall design: Examination of AR, FoxA1, GR, H3K4me2 binding sites and DHS sites in parental and FoxA1 depleted LNCaP-1F5 cells.

INSTRUMENT(S): Illumina Genome Analyzer (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Olli A. Jänne  

PROVIDER: GSE30623 | GEO | 2011-09-14

SECONDARY ACCESSION(S): PRJNA154785

REPOSITORIES: GEO

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