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M6A RNA modification controls reproductive development and metabolic adaptation in the human parasite Schistosoma japonicum [RNA-seq]

ABSTRACT: N6-Methyladenosine (m6A) is an abundant eukaryotic post-transcriptional mRNA modification, which plays pivotal role in regulating RNA metabolism. m6A is crucial for dynamic processes in many parasites, however, its presence, roles, and contribution to Schistosoma japonicum, a parasitic flatworm with a complex lifecycle involving dynamic transcriptional reprogramming, remain entirely unexplored. Here, we report the first evidence that m6A is abundant on S. japonicum RNA, and demonstrate its critical contribution to parasite biology. We identify the m6A writer as a crucial regulator of female reproductive development, including ovary morphogenesis and egg production, and in orchestrating metabolic reprogramming essential for survival and parasitism in male worms. Given the central role of eggs in host pathology and transmission, our findings uncover a key regulatory layer in schistosome biology and pinpoint m6A deposition as a potential target for anti-schistosomiasis interventions.

ORGANISM(S): Schistosoma japonicum

PROVIDER: GSE306704 | GEO | 2025/09/02

REPOSITORIES: GEO

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