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High-resolution mapping of IRF4 translocations in children and adults large B-cell lymphomas [CytoScanHD_Array]

ABSTRACT: Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) predominantly affects children and young adults (CAYA) presenting as localized disease with excellent prognosis. Although IRF4::IGH translocations are demonstrable in most tumors, cryptic rearrangements have been suggested. Next-generation sequencing (NGS) studies have identified a distinct mutational landscape. Whether large B-cell lymphomas (LBCL) harboring IRF4 rearrangements in adults represent the same biological entity remains uncertain. A total of 35 pediatric and young adult (CAYA) patients diagnosed with LBCL-IRF4 (38/42 positive by fluorescence-in-situ-hybridization, FISH) and 7 adult LBCL with IRF4-R were analyzed with integrative molecular approach.

ORGANISM(S): Homo sapiens

PROVIDER: GSE307279 | GEO | 2026/09/01

REPOSITORIES: GEO

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