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TGF-alpha/EGFR signalling mediates retinoic acid-induced lung repair

ABSTRACT: Retinoic acid (RA) signalling is an important regulator of lung development and repair. To investigate the molecular mechanisms underlying RA-mediated responses in lung endothelial cells, we profiled the gene expression of human pulmonary microvascular endothelial cells (HPMECs) treated with RA or ethanol (EtOH) vehicle control. Whole-genome expression analysis using Affymetrix Human U133 Plus 2.0 GeneChips identified transcriptional changes associated with angiogenesis, wound healing, and signalling pathways relevant to alveolar repair.

ORGANISM(S): Homo sapiens

PROVIDER: GSE307491 | GEO | 2026/07/02

REPOSITORIES: GEO

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