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Spatial chromatin architecture and accessibility co-profiling of mammalian tissues

ABSTRACT: Recent advancements of spatial omics techniques have enabled the profiling of different molecular features with spatial information. We developed Spatial-ATAC-Hi-C, which can provide spatially resolved, genome-wide joint-profiling of 3D genome organization and chromatin accessibility on tissue slides. Applying Spatial-ATAC-Hi-C in mouse and human brains, we revealed distinct chromatin architecture features and gene regulatory programs of different types of neuron and non-neuron cells in their original tissue locations.

ORGANISM(S): Mus musculus

PROVIDER: GSE307620 | GEO | 2026/07/01

REPOSITORIES: GEO

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