Transcriptomics

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Effect of TTYH2 Knockout on Gene Expression During DMXAA Treatment in Mouse Peritoneal Macrophages [RNA-seq]


ABSTRACT: Beyond regulators of myeloid cell activity, the myeloid-derived cytokine network controlled by type I interferons (IFN-α/β, IFN) is of particular importance, serving as a central determinant bridging both innate and adaptive immunity. Here we report that TTYH2 potently restrains NF-κB/IRF signaling and the production of type I interferons. RNA-seq of DMXAA-stimulated Ttyh2 wildtype and knockout mice peritoneal macrophages revealed striking upregulation of type I IFN-stimulated genes, NF-κB regulators, cytokines/chemokines, antigen-presentation genes, costimulatory molecules, and adhesion/integrin signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE307668 | GEO | 2026/09/09

REPOSITORIES: GEO

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