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Gene expression change after LSD1 siRNA treatment in ER-negative breast cancer cells MDA-MB-231

ABSTRACT: Knock-down of LSD1 using siRNA approach induced regulation of several proliferation-associated genes in ER-negative breast cancer cells MDA-MB-231.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30775 | GEO | 2011/07/20

SECONDARY ACCESSION(S): PRJNA144327

REPOSITORIES: GEO

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Gene expression change after LSD1 siRNA treatment in ER-negative breast cancer cells MDA-MB-231

Project description:Knock-down of LSD1 using siRNA approach induced regulation of several proliferation-associated genes in ER-negative breast cancer cells MDA-MB-231. To identify changes on gene expression caused by treatment with siRNA directed against LSD1 (si) or control siRNA (control) in MDA-MB-231 cells, total RNA was purified from the cells after treatment for 6 days (2 rounds of transfection). Three biological replicates were used.

2011-07-19 | E-GEOD-30775 | biostudies-arrayexpress

Gene expression change after LSD1 siRNA treatment in ER-negative breast cancer cells MDA-MB-231

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Project description:Dicer, RNase III endonuclease, is an essential enzyme in miRNA biogenesis that regulates target gene expression, and it has been reported that aberrant expressions of Dicer associate with the clinical outcomes of patients in various cancers. To explore the miRNA differencial expression regulated by Dicer in MDA-MB-231/E1A cells, the microarray profiling analysis was employed to conduct differentially expressed miRNAs in stable MDA-MB-231/vector, MDA-MB-231/E1A, and MDA-MB-231/E1A/shDicer cells.

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The miRNA profiling in MDA-MB-231, MDA-MB-231/E1A and knockdown of Dicer in MDA-MB-231/E1A cells

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Project description:Identification of genes that are involved in self-seeding by comparing gene expression profiles between parental MDA-MB-231 cells and seeder cells (MDA-231-S1a and S1b) 2 replicates from each sample (parental MDA-MB-231, MDA-MB-231 S1a and MDA-MB-231 S1b) were analyzed

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siRNA-mediated HNRPA2B1 knock-down in MDA-MB-231 cells

Project description:Transcriptional profiling of MDA-MB-231 comparing the siRNA-mediated HNRPA2B1 knock-downs versus mock-transfected controls

2012-02-28 | GSE35757 | GEO

Expression profiles of MDA-MB-231, MDA-231 S1a and S1b

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Transcriptomic profiling change of MDA-MB-231 cells overexpressing DNAJC12

Project description:Purpose: DnaJ heat shock protein family (Hsp40) member C12 (DNAJC12) belongs to Hsp40/DnaJ protein family containing a J domain.The goal of this study is to compare the transcriptomic profiling change of MDA-MB-231 cells overexpressing DNAJC12 compared with MDA-MB-231 cells transfected with empty vector. Methods: 5×10^6 cells of each sample were collected, and total RNA was extracted using TRIZOL. After extraction, the RNA integrality was validated by Agilent 2100 bioanalyzer, and the qualified RNA was used to establish an RNA library, which was checked by quality control with Agilent 2100 bioanalyzer before sequencing. Transcriptome sequencing was achieved by Illumina Novaseq platform.

2023-10-07 | GSE191110 | GEO

siRNA-mediated HNRPA2B1 knock-down in MDA-MB-231 cells

Project description:Transcriptional profiling of MDA-MB-231 comparing the siRNA-mediated HNRPA2B1 knock-downs versus mock-transfected controls Three siRNA vs mock transfections

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