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MAIT cells at different developmental stages egress the thymus to colonize specific tissues and sense increases in peripheral ligands

ABSTRACT: MAIT but not iNKT cells can be selected by thymic epithelial cells, while both require CD4+CD8+ thymocytes for maturation. MAIT and iNKT cells have similar developmental dynamics and thymic-residency properties but proliferate at different developmental stages.MAIT cells exit the thymus in an S1PR-dependent manner at different maturation stages to colonize specific peripheral organs.PLZF+Tbet-RORgt- MAIT cells preferentially colonize the intestine in a CCR9-dependent manner.Thymic output contributes to peripheral MAIT and iNKT cell numbers at steady state. Thymic MAIT17 cells are activated and expand in colitis and after bacterial exposure.

ORGANISM(S): Mus musculus

PROVIDER: GSE308509 | GEO | 2026/04/13

REPOSITORIES: GEO

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