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CYP450-Mediated Detoxification and NF-κB/NLRP3-Driven Mechanisms in Emodin-Induced Hepatotoxicity in vitro and in vivo

ABSTRACT: Emodin, a bioactive compound abundant in Chinese medicinal herbs, possesses broad therapeutic potential but raises safety concerns due to conflicting reports of hepatotoxicity. This study investigated the toxicological mechanisms underlying emodin-induced liver injury. We showed that emodin induced dose-dependent cytotoxicity and hepatic injury in HepG2 cells. Moreover, emodin (400 mg/kg) induced hepatotoxicity in mice after administered for three weeks.This study delineates the metabolic detoxification pathways of emodin and elucidates its toxicological mechanisms.

ORGANISM(S): Mus musculus

PROVIDER: GSE308606 | GEO | 2025/09/24

REPOSITORIES: GEO

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CYP450-Mediated Detoxification and NF-κB/NLRP3-Driven Mechanisms in Emodin-Induced Hepatotoxicity in vitro and in vivo

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